This paper provides an overview of the entrepreneurial infrastructure in the Republic of Croatia, which is necessary for the economic development of individual countries. Emphasisis given to the technology centers and business incubators. Through the work of technology centers, science is connected with entrepreneurial practice, which results in the accelerated development of small and medium-sized enterprises, and ultimately the dynamic development of the modern economy. Entrepreneurship centers are established primarily with the aim of providing professional and educational assistance to entrepreneurs that is necessary to them at the beggining of the entrepreneurial venture. Business incubators are a modern business tool that contributes to tha local community and the national economy in general. They help mostly start up projects to enter into the market and with that affect the hiring of new employees. There are a very large number of technology centers and business incubators in the Republic of Croatia and here were presented Entrepreneurial Incubator PISMO - Sisak, Student Entrepreneurship Incubator of the Faculty of Economics in Split, Zagreb Innovation Center ZICER and the Technology Center Split.